The role of the microenvironment in tumor invasion
نویسندگان
چکیده
Fibroblasts and myofibroblasts in the tumor microenvironment are important players in tumor growth and metastasis because of their unique ability to coordinate events which increase cell proliferation and invasion especially in breast cancer. It has been experimentally shown that fibroblasts play an important role in promoting tumor growth. Our study illustrates a model in which tumor cells are able to communicate with these fibroblasts/myofibroblasts through proteinases for active invasion toward stroma near breast
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